Definition: BOTOX® Cosmetic (onabotulinumtoxinA) is the only FDA-approved treatment to temporarily improve both moderate to severe frown lines between the brows and crow’s feet in adults.


What Botox treats

Moderate to severe crow’s feet and moderate to severe frown lines.


Science Behind Botox:

BOTOX Cosmetic (onabotulinumtoxinA) targets one of the underlying causes of frown lines and crow’s feet— the repeated muscle contractions from frowning and squinting over the years. BOTOX Cosmetic temporarily reduces this muscle activity so you’ll begin to notice a visible smoothing of these lines.


Treatment procedure

BOTOX Cosmetic (onabotulinumtoxinA) targets one of the underlying causes of frown lines and crow’s feet— the repeated muscle contractions from frowning and squinting over the years. BOTOX Cosmetic temporarily reduces this muscle activity so you’ll begin to notice a visible smoothing of these lines. For temporary improvement of moderate to severe crow’s feet, your doctor will inject BOTOX Cosmetic into the muscle surrounding the sides of your eyes— called the orbicularis oculi muscles. For temporary improvement of moderate to severe frown lines, your doctor will inject BOTOX Cosmetic into two muscles—the corrugator and procerus muscles.

The treatment takes approximately 10 minutes and requires minimal downtime or recovery—it’s often called a lunchtime procedure.


Side effects

Three percent of patients experienced eyelid drooping in the frown line studies and one percent of patients experienced eyelid swelling in the crow’s feet studies. Other possible side effects include discomfort or pain at the injection site; headache; and eye problems, such as double vision, blurred vision, drooping eyelids and swelling of eyelids. This is not a complete list of the possible serious side effects of BOTOX Cosmetic.


Results

In two clinical studies for moderate to severe crow’s feet, 26.1 percent and 20.3 percent of people had ≥ 2-grade improvement at day 30. In one of these studies, 67.9 percent of people had mild or no crow’s feet at day 30 after treatment. In clinical studies for moderate to severe frown lines, 80 percent of patients assessed by physicians had significant improvement at day 30.

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